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Micro-computed tomography (micro-CT) is considered as one of the emerging imaging techniques for drug discovery and for providing a better understanding of in-vivo pathology.
Micro-CT in Pre-Clinical Studies 1 Micro-CT in Pre-Clinical Studies 2 Micro-CT in Pre-Clinical Studies 3

 

Preclinical studies are a crucial part of the drug development process that involves testing and evaluating the safety and efficacy of new drugs or therapies before they are tested in human clinical trials.

Micro-computed tomography (micro-CT) is considered as one of the emerging imaging techniques for drug discovery and for providing a better understanding of in-vivo pathology. Micro-CT is a non-invasive imaging technique that allows researchers to visualize and study the internal structure of small animals, such as mice and rats, in high resolution. This imaging technique is particularly useful in preclinical studies for drug development, as it can provide valuable information on the effects of a drug candidate on the anatomy and physiology of small animals.

Over the past decade, the number of publications using micro-computed tomography (μCT) imaging in preclinical in-vivo studies has risen exponentially. Higher resolution is the key technical advancement that have allowed researchers to capture increasingly detailed anatomical images of small animals and to monitor the progression of disease in small animal models.

Some of the micro-CT applications in preclinical studies are:

  1. Bone analysis
  2. Tumor detection and quantification
  3. Vascular imaging
  4. Longitudinal lung-function measurements
  5. Assessing BIC (Bone-to-Implant-Contrast)
  6. Quantification of tumor angiogenesis
  7. Assessment of longitudinal growth of liver metastases
  8. Imaging for fine location and quantification of ischemic lesion and edema in mouse
  9. Imaging of
    1. tooth and jaw bone in mice
    2. human teeth samples
    3. biological implants
    4. biological scaffolds and their effects
    5. pharmaceutical products and their effects

 

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