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The internal structure of a tablet or any other solid dosage drug and even the parts used in the packaging, including sprays, can be observed without destroying the sample by X-ray computed tomography (CT).
Micro-CT in Pharmacology

The internal structure of a tablet or any other solid dosage drug and even the parts used in the packaging, including sprays, can be observed without destroying the sample by X-ray computed tomography (CT). In some cases, in addition to the need for a non-destructive observation method, there is a need to observe micron-sized details; in these cases, the resolution of the CT imaging is not enough, and X-ray micro-computed tomography is an alternative. This method has many applications in pharmaceutics development:

  • Tablet Development
    • To determine the thickness, shape and size of the layers in multilayer tablets
    • To assess the morphology and pore-size distribution
    • Assessment of the thickness uniformity of a functional coating, detection of the holes and cracks in the coating and their dimensions
    • Determination of the thickness and integrity of the capsule’s solid shell and its welded seam
    • To evaluate the defects in or damage to the internal structure of a compacted tablet
    • To determine the distribution of an active ingredient or functional excipient in a tablet or a capsule
    • To measure the uniformity and density variation of pharmaceutical samples
    • To detect and locate the foreign matter such as a metal particle within a solid dosage form
    • Counterfeit product detection
  • Inhaler, spray, syringe
    • Non-destructive inspection of the internal parts
  • Packaging and sealing
    • To Locate gaps in seal interfaces or other leakage pathways in packaging
Click here to see all the scientific papers on "Micro-CT in Pharmcy and Pharmacology".

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